Acta Neuropathologica Communications August 2013

This book contains open access research articles from August of 2013 published in Acta Neuropathologica Communications: Topics include: Neuropathology of brain and spinal malformations in a case of monosomy 1p36; Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues; Myelin alters the inflammatory phenotype of macrophages by activating PPARs; CSF Presenilin-1 complexes are increased in Alzheimer's disease; Disorganization of neocortical lamination in focal cortical dysplasia is brain-region dependent: evidence from layer-specific marker expression; Immune complex formation impairs the elimination of solutes from the brain: implications for immunotherapy in Alzheimer's disease; Reducing TDP-43 aggregation does not prevent its cytotoxicity; Pathological assessments for the presence of hexanucleotide repeat expansions in C9ORF72 in Alzheimer's disease; Blast overpressure induces shear-related injuries in the brain of rats exposed to a mild traumatic brain injury; Protective effects of decay-accelerating factor on blast-induced neurotrauma in rats; Simulated surgical-type cerebral biopsies from post-mortem brains allows accurate neuropathological diagnoses in the majority of neurodegenerative disease groups; Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimer's disease brain.