Acta Neuropathologica Communications December 2013

This book contains open access research articles from December of 2013 published in Acta Neuropathologica Communications. Topics include: Myositis facilitates preclinical accumulation of pathological prion protein in muscle; Molecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathies; Genetic CJD with a novel E200G mutation in the prion protein gene and comparison with E200K mutation cases; Heavy metals in locus ceruleus and motor neurons in motor neuron disease; Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice; A central role for dityrosine crosslinking of Amyloid-beta in Alzheimer's disease; Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis; T cell-activation in neuromyelitis optica lesions plays a role in their formation.