BLyS Ligands and Receptors

BLyS Ligands and Receptors
Author: Michael P. Cancro
Publisher: Springer Science & Business Media
Total Pages: 296
Release: 2009-09-18
Genre: Medical
ISBN: 1603270132

Download BLyS Ligands and Receptors Book in PDF, Epub and Kindle

Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activation, and homeostasis. Previously, the B-cell antigen receptor (BCR) was viewed as the sole mediator of these parameters, in which BCR signals were not only dominant but were also linearly related to consequent outcomes. However, appreciating that BLyS signaling is an equal partner in establishing and maintaining B-cell pools in- cated that additional regulatory complexity – apparently based on population density and homeostatic demands – had to be included in models of B-cell behavior. This mounting interest was ampli?ed by evidence of a clear relationship to autoim- nity. The resulting ?urry of research activity has yielded a wealth of information and insights, impacting basic concepts in B-cell tolerance and activation as well as revealing novel translational strategies for autoimmunity, neoplasia, and transplant tolerance. This book includes 12 chapters that together yield an overview of these advances and ideas. The initial excitement generated by associations with humoral autoimmunity, coupled with profound B lineage phenotypes in knockout mouse models, prompted immediate questions: What do these receptors and cytokines look like, how do they interact, what cells express them, and how does this inform our understating of their biology? Indeed, probing the structural features of BLyS family ligands and rec- tors has afforded substantial insight, as have studies directed toward understanding the basic biological actions of these molecules.


BLyS Ligands and Receptors
Language: en
Pages: 296
Authors: Michael P. Cancro
Categories: Medical
Type: BOOK - Published: 2009-09-18 - Publisher: Springer Science & Business Media

GET EBOOK

Discovery of the BLyS (also known as BAFF) family of ligands and receptors has yielded a paradigm shift in our view of B-lymphocyte selection, survival, activat
Blys Ligands and Receptors
Language: en
Pages: 304
Authors: Michael P. Cancro
Categories:
Type: BOOK - Published: 2009-09-01 - Publisher:

GET EBOOK

Ligand-Receptor Energetics
Language: en
Pages: 196
Authors: Irving M. Klotz
Categories: Science
Type: BOOK - Published: 1997-03-14 - Publisher: John Wiley & Sons

GET EBOOK

Energetische Wechselbeziehungen zwischen Ligand und Rezeptor sind besonders bei der Wechselwirkung kleiner Moleküle mit größeren unter Bildung komplexer Makr
Cell Surface Receptors: A Short Course on Theory and Methods
Language: en
Pages: 251
Authors: Lee E. Limbird
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

GET EBOOK

Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of m
Receptors
Language: en
Pages: 376
Authors: Douglas A. Lauffenburger
Categories: Science
Type: BOOK - Published: 1996-01-11 - Publisher: Oxford University Press

GET EBOOK

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating