Electronic Structure And Reactivity In Iron Catalyzed Carbon Carbon Cross Coupling Reactions And Dioxygen Reduction

"This dissertation reports research in elucidating origins of reactivity and mechanism in homogeneous iron catalyzed carbon-carbon (C-C) cross-coupling reactions (Chapters 2 and 3) and iron-mediated reduction of dioxygen (O2) in heterogeneous fuel cell materials (Chapter 4). Chapter 2 reports a systematic spectroscopic and computational investigation of well-defined iron(II)- and iron(I)-bisphosphine complexes supported by bisphosphine ligands relevant to C-C cross-coupling catalysis (bisphosphine = SciOPP, dpbz, dppe, tBudppe, and Xantphos). Both iron(II) and iron(I) centers have been implicated in proposals for reactive iron intermediates in C-C cross-coupling catalysis, and thus the relative effects of bisphosphine ligation on the overall electronic structure and bonding within iron(II) and iron(I) complexes presented in this study provide insight into aspects of precatalyst design that potentially affect reactivity pathways within these reactions. Chapter 3 extends past the study of iron-bisphoshine precatalysts to elucidating reactive, transmetalated iron intermediates within C(sp)-C(sp3) Kumada cross-coupling. Specifically, the system studied uses the FeX2(SciOPP) precatalyt (X = Cl or Br) to catalyze the cross-coupling of the alkynyl Grignard reagent (triisopropylsilyl)ethynylmagnesium bromide (TIPS-CC-MgBr) with cycloheptyl bromide. Herein the solution stability and reactivity of alkynylated iron(II)-SciOPP species are characterized, aspects that were observed to be affected by the nature of the reaction solvent. Importantly, this work provides the first insight into the generality of iron(II)-bisphosphine reactive species in systems employing nucleophilic coupling partners lacking ? hydrogens prone to elimination and, furthermore, defines the lack of productive reactivity of in situ generated iron(I) species in these systems. Finally, Chapter 4 presents a new approach to identifying and characterizing potential iron active sites in polymer electrolyte fuel cell (PEFC) materials for reduction of O2. 57Fe Ms̲sbauer spectroscopy and nuclear resonance vibrational spectroscopy (NRVS) were used to elucidate the change in iron speciation and iron-based vibrational modes that accompany electrochemical reduction of a polyaniline-based iron-PEFC and subsequent treatment with nitric oxide (NO) probe molecule. These experimental data were complemented with density functional theory calculations (DFT) to provide insight into the structure of potential iron active sites and the accessibility of Fe-N/O cleavage products, species that may be similar to those accessed during O2 reduction."--Pages xi-xii.