Eutectic Solvents

Eutectic Solvents
Author: Piotr Cysewski
Publisher: MDPI
Total Pages: 126
Release: 2021-02-24
Genre: Science
ISBN: 3036500227

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Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutical ingredient (API) solubility, but also due to their non-toxicity. This fortunate conjuncture allows for designing new media for escalation and controlled release of APIs. For example, composition optimisation of a series of NADES comprising choline chloride with multi-hydroxyl compounds was successfully performed for a set of sulphonamide-based drugs. These results confirmed that NADES in general, and the ones based on choline chloride and glycerol particularly, are an attractive alternative to traditional solvents for sulphonamide dissolution. Experiments augmented with in silico modelling can offer deeper insights into the thermodynamic characteristics of these systems and an explanation for the origin of the observed solubility enhancement. Research of this type offers universal resolutions to the problem of low solubility issues for many types of drugs. Of particular interest is that such screening is not restricted to artificial in vitro environments but can be also easily adopted for the study of modelled in vivo situations. One of very important and interesting examples is a new curcumin–NADES formulation preserving its beneficial properties even after dilution with FaSSIF solution, which mimicks intestinal absorption.


Eutectic Solvents
Language: en
Pages: 126
Authors: Piotr Cysewski
Categories: Science
Type: BOOK - Published: 2021-02-24 - Publisher: MDPI

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Natural deep eutectic solvents (NADES) are pharmaceutically accepted systems not only because they typically offer a serious enhancement of active pharmaceutica
Deep Eutectic Solvents
Language: en
Pages: 200
Authors: Yizhak Marcus
Categories: Science
Type: BOOK - Published: 2018-12-05 - Publisher: Springer

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This is one of the first books fully dedicated to the rapidly advancing and expanding research area of deep eutectic solvents. Written by the internationally re
Deep Eutectic Solvents
Language: en
Pages: 384
Authors: Diego J. Ramón
Categories: Science
Type: BOOK - Published: 2020-01-13 - Publisher: John Wiley & Sons

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A useful guide to the fundamentals and applications of deep eutectic solvents Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic
Deep Eutectic Solvents for Pretreatment of Lignocellulosic Biomass
Language: en
Pages: 98
Authors: Pratima Bajpai
Categories: Science
Type: BOOK - Published: 2021-08-20 - Publisher: Springer Nature

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This book focuses on the properties of deep eutectic solvents (DESs) and recent advances in their application in lignocellulosic biomass processing. Lignocellul
Deep Eutectic Solvents for Medicine, Gas Solubilization and Extraction of Natural Substances
Language: en
Pages: 321
Authors: Sophie Fourmentin
Categories: Science
Type: BOOK - Published: 2020-10-19 - Publisher: Springer Nature

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Initially considered as a sub-class of ionic liquids, eutectic mixtures are formed by mixtures of low cost, often biodegradable Lewis or Bronsted acids and base