Proteopathic Seeds And Neurodegenerative Diseases
Download Proteopathic Seeds And Neurodegenerative Diseases full books in PDF, epub, and Kindle. Read online free Proteopathic Seeds And Neurodegenerative Diseases ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Proteopathic Seeds and Neurodegenerative Diseases
Author | : Mathias Jucker |
Publisher | : Springer Science & Business Media |
Total Pages | : 163 |
Release | : 2013-03-27 |
Genre | : Medical |
ISBN | : 3642354912 |
Download Proteopathic Seeds and Neurodegenerative Diseases Book in PDF, Epub and Kindle
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society.
Proteopathic Seeds and Neurodegenerative Diseases Related Books
Pages: 163
Pages: 114
Pages: 400
Pages: 286
Pages: 158