Acta Neuropathologica Communications May 2013

This book contains open access articles from May of 2013 published in Acta Neuropathologica Communications. Articles include: ANC: High quality, fast publication, open access; Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease; Intrastriatal injection of interleukin-1 beta triggers the formation of neuromyelitis optica-like lesions in NMO-IgG seropositive rats; The influence of DNA repair on neurological degeneration, cachexia, skin cancer and internal neoplasms: autopsy report of four xeroderma pigmentosum patients (XP-A, XP-C and XP-D); The prion hypothesis in Parkinson's disease: Braak to the future; Do brain T2/FLAIR white matter hyperintensities correspond to myelin loss in normal aging? A radiologic-neuropathologic correlation study; ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies; ALDH1 is an immunohistochemical diagnostic marker for solitary fibrous tumours and haemangiopericytomas of the meninges emerging from gene profiling study; Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases; Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U; NG2 cells, a new trail for Alzheimer's disease mechanisms?; Extensive aggregation of alpha-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site; Direct detection of alpha synuclein oligomers in vivo; Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis; Peripheral nervous system insulin resistance in ob/ob mice; Promoter DNA methylation regulates progranulin expression and is altered in FTLD; Evidence for new targets and synergistic effect of metronomic celecoxib/fluvastatin combination in pilocytic astrocytoma; The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma; Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and alpha-KG; Immunohistochemistry is highly sensitive and specific for detection of BRAF V600E mutation in pleomorphic xanthoastrocytoma.