Neuron-To-Neuron Wild-Type Tau Protein Transfer Through a Trans-Synaptic Mechanism

Neuron-To-Neuron Wild-Type Tau Protein Transfer Through a Trans-Synaptic Mechanism
Author: Applied Research Press
Publisher: CreateSpace
Total Pages: 42
Release: 2015-08-09
Genre:
ISBN: 9781516825035

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In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the hierarchical pathways of this neurodegeneration have been well established in Alzheimer's disease (AD) and other sporadic tauopathies such as argyrophilic grain disorder and progressive supranuclear palsy but the molecular and cellular mechanisms supporting this progression are yet not known. These pathways appear to be associated with the intercellular transmission of pathology, as recently suggested in Tau transgenic mice. However, these conclusions remain ill-defined due to a lack of toxicity data and difficulties associated with the use of mutant Tau. Taken together, these results support a novel mechanism for Tau protein transfer compared to previous reports based on transgenic models with mutant cDNA. It also demonstrates that mutant Tau proteins are not suitable for the development of experimental models helpful to validate therapeutic intervention interfering with Tau spreading.


Neuron-To-Neuron Wild-Type Tau Protein Transfer Through a Trans-Synaptic Mechanism
Language: en
Pages: 42
Authors: Applied Research Press
Categories:
Type: BOOK - Published: 2015-08-09 - Publisher: CreateSpace

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In sporadic Tauopathies, neurofibrillary degeneration (NFD) is characterised by the intraneuronal aggregation of wild-type Tau proteins. In the human brain, the
Tau oligomers
Language: en
Pages: 114
Authors: Jesus Avila
Categories: Medicine (General)
Type: BOOK - Published: 2014-08-18 - Publisher: Frontiers E-books

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Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other n
Utilizing Drosophila Primary Neurons to Study Human Tau Propagation
Language: en
Pages: 75
Authors: Elizabeth A Murphy
Categories: Alzheimer's disease
Type: BOOK - Published: 2018 - Publisher:

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Aggregates of the microtubule stabilizing protein, tau, are found in the neurofibrillary tangles (NFTs) of Alzheimer's disease (AD) patients. When phosphorylate
Proteopathic Seeds and Neurodegenerative Diseases
Language: en
Pages: 163
Authors: Mathias Jucker
Categories: Medical
Type: BOOK - Published: 2013-03-27 - Publisher: Springer Science & Business Media

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The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initia
Study of the Neuron-Astrocyte Relationship in a Rodent Model of Tauopathy
Language: en
Pages: 0
Authors: Anastasie Mate de Gerando
Categories:
Type: BOOK - Published: 2019 - Publisher:

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Tauopathies are neurodegenerative diseases characterized by the aggregation of Tau protein in neurons, astrocytes and other cell types. However, the mechanisms