Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors

Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors
Author: Helena Simek Tosino
Publisher: Logos Verlag Berlin GmbH
Total Pages: 440
Release: 2024-06-03
Genre: Science
ISBN: 3832582614

Download Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors Book in PDF, Epub and Kindle

This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to synthesize differently functionalized indole systems bearing various substituents in the positions N-1, C-2, C-3, C-5 and C-6 was shown. Additionally, this reaction was systematically studied in a kinetic study in an in-house assembled capillary photo-microreactor. Further derivatization of the final F-tagged 3-acylindoles by the cleavage of the perfluorinated chain yielded a library of novel indole-3-carboxylic acid and indole-3-carboxylic acid ester derivatives. A straightforward and efficient four-step methodology for the synthesis of desired indole derivatives with high yields for single steps and the whole sequence was developed. Variing the conditions of single steps showed that all three steps of the reaction route to the cyclization precursors can be performed using the same solvent and base, providing the possibility to conduct this sequence as a continuous-flow without the need for in-line solvent switch or base exchange and without compromises with respect to the selectivity and yields of single steps.


Synthesis of derivatized indoles by photocatalyzed reactions in batch- and microreactors
Language: en
Pages: 440
Authors: Helena Simek Tosino
Categories: Science
Type: BOOK - Published: 2024-06-03 - Publisher: Logos Verlag Berlin GmbH

GET EBOOK

This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to s
Photocatalysis
Language: en
Pages: 395
Authors: Dionysios D Dionysiou
Categories: Science
Type: BOOK - Published: 2016-03-30 - Publisher: Royal Society of Chemistry

GET EBOOK

From environmental remediation to alternative fuels, this book explores the numerous important applications of photocatalysis. The book covers topics such as th
C-H Bond Activation and Catalytic Functionalization I
Language: en
Pages: 269
Authors: Pierre H. Dixneuf
Categories: Science
Type: BOOK - Published: 2015-12-18 - Publisher: Springer

GET EBOOK

The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometalli
Zinc Catalysis
Language: en
Pages: 326
Authors: Stephan Enthaler
Categories: Technology & Engineering
Type: BOOK - Published: 2015-04-27 - Publisher: John Wiley & Sons

GET EBOOK

Filling the gap in the market for comprehensive coverage of this hot topic, this timely book covers a wide range of organic transformations, e. g. reductions of
Photochemistry of Organic Compounds
Language: en
Pages: 583
Authors: Petr Klán
Categories: Science
Type: BOOK - Published: 2009-03-23 - Publisher: John Wiley & Sons

GET EBOOK

Photochemistry of Organic Compounds: From Concepts to Practice provides a hands-on guide demonstrating the underlying principles of photochemistry and, by refer