Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy

Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy
Author: Noha Mousaad Elemam
Publisher: Frontiers Media SA
Total Pages: 144
Release: 2023-09-13
Genre: Medical
ISBN: 2832534929

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One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.


Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy
Language: en
Pages: 144
Authors: Noha Mousaad Elemam
Categories: Medical
Type: BOOK - Published: 2023-09-13 - Publisher: Frontiers Media SA

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One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to imm
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Type: BOOK - Published: 2022-05-16 - Publisher: Springer Nature

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This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It a
Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment
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Type: BOOK - Published: 2019-03-20 - Publisher: Frontiers Media SA

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Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support di
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Pages: 326
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Type: BOOK - Published: 2020-03-25 - Publisher: Springer Nature

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This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise